Hypomethylation of CpG targets over the X chromosome; hypomethylation in genes associated with immune operate, transport activity and metabolism; hypomethylation of SNORD, SULT2A1, COMT; In a twin examine of discordant SLE twins, B cells had more strong methylation variations than other mobile types, with hypermethylation of CpGs in TRAF5, CXCR5 a